The AMP-activated protein kinase (AMPK) system was discovered in mammalian cell extracts as activities that phosphorylated and inactivated key enzymes of lipid biosynthesis, that is, acetyl-CoA ...

Scientists are investigating how exercise-triggered stress reshapes the cell’s energy systems, and whether those same mechanisms could eventually help counter metabolic disease. Don’t like the gym?

Researchers identified a critical AMPK phosphorylation site that regulates mitochondria, muscle contraction, and sugar breakdown during exercise. Mice lacking the site showed poor endurance, and ...

Adenosine monophosphate (AMP)-activated protein kinase (AMPK) plays an important role in cellular energy homeostasis, helping in growth regulation and metabolic reprogramming in eukaryotes. The AMPK ...

This graphic illustration of a study in Cell Reports shows how a molecular energy regulator in cells, AMPK, is required for astrocytic glycoses, lactate production and lactate shuttle to bio-energize ...

Researchers at the Salk Institute report they might have solved the long-standing mystery around how the protein complex AMPK can both hinder and help cancer. The lab of Reuben Shaw, Ph.D., director ...

Grahame Hardie received funding from Cancer Research UK for this research. The basic unit of all living things is the cell – and the human body contains tens of trillions of them. Cancer can be ...

A study from researchers at KAIST (Korea Advanced Institute of Science and Technology) is providing new insights into a cellular energy pathway that has been linked to longer lifespan. The research, ...

Long thought to suppress cancer by slowing cellular metabolism, the protein complex AMPK also seemed to help some tumors grow, confounding researchers. Now, Salk Institute researchers have solved the ...