We evaluated a family in which five siblings were affected by autosomal recessive sensorineural hearing loss. Despite the presumably shared cause of the disorder, there were clinically significant ...

Boston, MA - The improvement of intracellular calcium cycling, through overexpression of the sarcoplasmic reticulum CA 2+ ATPase pump (SERCA2a), reduces arrhythmias and restores contractile function ...

The enzyme is the calcium-pumping Ca2+-ATPase - an ion pump protein that maintains a concentration of calcium inside the cell, which is about 20,000 times lower than outside. Only, it does not pump ...

High-speed pumps: Cells use high-speed pumps to pump calcium ions out of their interior. A team has created the first comprehensive transport model of plasma membrane CaATPase (PMCA) to study calcium ...

Parasitic wasps switch off the immune systems of fruit flies by draining calcium from the flies' blood cells, a finding that offers new insight into how pathogens break through a host's defenses.

Nuclear calcium is an important mediator of activity-dependent gene expression in the nervous system. It serves as a signalling end point in synapse-to-nucleus communication and activates gene ...

Interactions of two voltage-gated calcium channels and a pump enable separate control of exocytosis and endocytosis at chemical synapses. Chemical synapses transmit information within the nervous ...