The hypoxia response has been found to be vital for the proper formation of the heart ventricles during gestation, adding an additional stage to embryonic development. A new study from the Centro ...

In the left part can be seen multi-omics analysis suggested some proteins (histone / non-histone), protein lactylation, and genes change significantly at different developmental stages (1 w [week], 6 ...

New Approach Methodologies (NAMs) are revolutionizing disease modeling with human-based models that enhance predictive accuracy. iPSC-derived cardiac organoids lead this innovation, offering insights ...

Fibroblasts are an essential component of the heart, as they play key roles in its structure, development and response to cardiac damage. In this context, a recent study led by the University of ...

Fibroblasts are an essential component of the heart, as they play key roles in its structure, development and response to cardiac damage. In this context, a recent study led by the University of ...

An international team of researchers has discovered a natural mechanism that protects the heart from heart failure with preserved ejection fraction (HFpEF), a serious condition in need of effective ...

Heart disease remains the leading cause of death worldwide, yet progress in understanding and treating cardiac disorders is limited by the shortcomings of existing experimental models. Traditional ...

This study is led by Dr. Xiaodong Luan (Institute of Clinical Medicine, Peking Union Medical College Hospital), Dr. Shuyang Zhang (Department of Rare Diseases, Peking Union Medical College Hospital) ...