New technology enables the insertion of a large segment of DNA into a genome, potentially expanding gene therapy treatment ...

PHILADELPHIA— A new approach to the genetic engineering of cells promises significant improvements in speed, efficiency, and reduction in cellular toxicity compared to current methods. The approach ...

One small atom can make a big difference in a molecule’s pharmacological properties. Especially if that atom is a nitrogen. Chemists at the University of Oklahoma have now unveiled a new strategy for ...

Incorporating silicon into drug scaffolds could help to fine-tune their medicinal properties. The carbon-silicon bond is ...

Researchers have opened a transformative chapter in agricultural biotechnology by unveiling virus-induced genome editing (VIGE) techniques for Solanaceous crops, a group that includes tomatoes, ...

CRISPR-Cas9 is widely used to edit the genome by studying genes of interest and modifying disease-associated genes. However, this process is associated with side effects including unwanted mutations ...

A novel genome editing technique, NICER, is based on the creation of multiple nicks in single DNA strands by nickase. The method can correct heterozygous mutations using two mechanisms: multiple nicks ...

Advanced biotechnology repurposes two bacterial immune systems to correct large stretches of DNA. Human cells that have been edited with the new retron-based gene editing technology. Orange dots mark ...