Long-Term Follow-Up of the Prospective Randomized AATT Study (Autologous or Allogeneic Transplantation in Patients With Peripheral T-Cell Lymphoma) Novel cancer drugs can produce higher and more ...

A seminal paper by Miller and Brody [1] clearly laid the general framework on why we should abandon the term "clinical equipoise" in research. Their paper argued that the concept of equipoise (also ...

In this issue of the Journal of Clinical Oncology, Saltz et al 1 report the results of Cancer and Leukemia Group B (CALGB) 89803, a prospective randomized phase III trial of adjuvant therapy for ...

RCTs incorporate several methodological characteristics intended to maximize the validity of conclusions about the efficacy and safety of the intervention under study. 1 First, they employ a ...

Freedman justified this by saying: "[I]t is necessary that the clinical investigator be in a state of genuine uncertainty regarding the comparative merits of treatments A and B for a population. If a ...