In a way, sequencing DNA is very simple: There's a molecule, you look at it, and you write down what you find. You'd think it would be easy—and, for any one letter in the sequence, it is. The problem ...

Scheme showing the structure of cytosine, 5-methylcytosine, and 5-hydroxymethylcytosine. Adding a methyl group to the DNA base cytosine represses gene expression in mammalian cells. To remove the ...

In 1995, with the Human Genome Project underway, sequencing was all the rage. Scientists working on the project cloned short fragments of the whole genome and used Sanger sequencing to determine the ...

A research team led by the A*STAR Genome Institute of Singapore (A*STAR GIS) have developed a method to accurately and efficiently read DNA containing non-standard bases—a task once thought too ...

Prabowo Subianto, the president of Indonesia, recently generated a lot of interest when he disclosed that a whole genome ...