Pirtobrutinib demonstrated efficacy in MCL and CLL/SLL, with over 70% of MCL and 80% of CLL/SLL patients reporting stable or improved symptoms. The BRUIN phase 1/2 study highlighted significant patient-reported outcomes, though small cohort sizes limited ...

MCL-1, an anti-apoptotic BCL-2 family member that is essential for the survival of multiple cell lineages, is also among the most highly amplified genes in cancer. Although MCL-1 is known to oppose cell death, precisely how it functions to promote survival ...

McLaren Racing has revealed the name of the FIA Hypercar that will bring the iconic motorsport brand back to top-level endurance racing. The McLaren MCL-HY will compete for overall honors in the FIA World Endurance Championship and the 24 Hours of Le Mans from 2027.