The key protein complex PRC2 was discovered decades ago to silence genes, but new findings by Frederic Berger and his group at the Gregor Mendel Institute show that PRC2 represses transposons in a ...
RIKEN researchers have shed new light on the roles two protein complexes play in the enigmatic process of turning off one X chromosome in female mammals. This finding could help researchers discover ...
Deep inside our cells— each one complete with an identical set of genes— a molecular machine known as PRC2 plays a critical role in determining which cells become heart cells, vs. brain or muscle or ...
Effective targeted therapies for small cell lung cancer (SCLC) remain a significant challenge. Targeting the epigenome to overcome immune evasion and chemoresistance represents a promising strategy to ...
Interplay between chromatin-associated complexes and modifications critically contribute to the partitioning of epigenome into stable and functionally distinct domains. Yet there is a lack of ...
Polycomb repressive complex 2 (PRC2) was discovered decades ago in Drosophila, where it was found to be a key controller of developmental genes. Further analyses showed that PRC2 modifies chromatin ...
Abstract HighlightsRinzimetostat is a potent and highly selective next-generation allosteric PRC2 inhibitor targeting the EED subunit that has demonstrated potential best-in-class efficacy and safety ...
Cancers emerge from many different paths. One path begins early, in embryonic development, when a protein complex called PRC2, which regulates cell differentiation, identity, and plasticity, becomes ...
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