A new research paper titled "Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span" has been published in Aging. The decrease in the podocytes' lifespan and health span ...

Unlike other human stem cells, Induced pluripotent stem cells (iPS cells) can be produced directly from adult cells. Now, researchers have shown that human kidney podocytes produced from iPS cells via ...

The kidneys are vital organs that sustain life by filtering the blood and producing urine. This filtration process takes place in specialized structures called glomeruli, where podocytes play a ...

A single podocyte was reconstructed in three dimensions based on serial glomerular section images obtained by array tomography. The three-dimensional reconstruction enabled quantitative volume ...

Human stem cells are of great interest in the fields of regenerative medicine and medical research because they reproduce indefinitely and can differentiate into every other cell type found in the ...

Although the pathophysiology of mesangial cells has long been considered to be the major factor in the development of glomerulosclerosis in type 1 or type 2 diabetes, more recent evidence suggests ...

A newly-established protocol offers hope for kidney disease modeling, drug discovery, and potential cell therapies. Previous work from the Wyss Institute at Harvard University established a protocol ...

Abatacept (cytotoxic T-lymphocyte–associated antigen 4–immunoglobulin fusion protein [CTLA-4–Ig]) is a costimulatory inhibitor that targets B7-1 (CD80). The present report describes five patients who ...

Chronic kidney disease can quietly reshape a life long before the first lab test comes back abnormal. More than 700 million people worldwide live with damaged kidneys, and for many, the risk begins in ...

BUFFALO, NY-August 8, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, “Inhibiting ...