There are many ways in which the genetic material DNA can be damaged, resulting in the development of diseases such as cancer. Certain forms of DNA damage are associated with so-called R-loops. These ...

R loops consist of RNA–DNA hybrids that accumulate at preferred regions all over the genome, such as pericentromeric DNA, telomeres, ribosomal DNA or transcription termination regions. R loops are an ...

Recently, the research team led by Wei Li and Chao Liu from Guangzhou Medical University Affiliated Women and Children's Medical Center, in collaboration with Fei Gao’s team from the Institute of ...

This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, ...

R-loops are unique structures in the cell, composed of RNA–DNA hybrids and a displaced single-stranded DNA, that are commonly found around transcribed genes. However, R-loops are also dynamic and ...

This study is achieved by Professor Wei Xu’s research team from Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences. The research team established mDRIP-seq, a ...

New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli. Genetically speaking, it's a bacterium's worst-case scenario: during transcription, newly minted RNA sticks to ...

Researchers have figured out how the human body keeps essential genes switched "on" and silences the vast stretches of genetic repeats and "junk" DNA. Researchers at the University of California, ...

Dysregulated R-loops can cause stalled replication forks and telomere instability. However, how R-loops are recognized and regulated, is still not well understood, particularly at telomeres. In a new ...