Transferrin is the principal iron-binding glycoprotein in vertebrate circulation, responsible for safe transport of ferric ions and regulation of systemic iron distribution. Each molecule comprises ...

The blood brain barrier (BBB) exists to protect the brain from pathogens and other toxins but makes central nervous system (CNS) diseases hard to treat with conventional drugs. For example, many ...

Incorporating structural constraints into pharmacokinetic studies of iron sucrose formulations. Results from assays conducted independently of one another can produce findings that are incompatible ...

A new study led by researchers at the Graduate Entry Medical School (GEMS), University of Limerick (UL) has found that people with low levels and very high levels of a commonly measured laboratory ...

Over the last three decades, scientists have devised molecular shuttles that slip enzymes, antibodies, and other molecules into the central nervous system (CNS) by attaching them to the transferrin ...

Low iron saturation occurs when the amount of iron in the blood decreases below the recommended range. Measuring transferrin is one way to determine iron saturation. Iron saturation refers to the ...

For decades scientists have sought a way to sneak large drugs across the blood-brain barrier. These efforts received a boost in 2011, when researchers led by Ryan Watts at Genentech, South San ...

Medizinische Universitätsklinik Freiburg, Abteilung Rehabilitative und Präventive Sportmedizin, Hugstetter Str 55, 79106 Freiburg, Germany Correspondence to: Dr Schumacher, Abtlg RP Sportmedizin, ...