Mar 4, 2025 · Over the last 30 years, NRF2 has evolved from being recognized as a transcription factor primarily involved in redox balance and detoxification to a well-appreciated master regulator of cellular...

Both Gclc and Gclm are characteristic NRF2 target genes, which establish NRF2 as a regulator of glutathione, one of the most important antioxidants in the body.

Nrf2 is responsible for regulating an extensive panel of antioxidant enzymes involved in the detoxification and elimination of oxidative stress and has been extensively studied in the disease …

Jul 24, 2025 · Nrf2 (Nuclear factor erythroid 2-related factor 2) is a protein in the human body that plays a significant role in cellular defense. It acts as a sensor, detecting various forms of stress within cells …

Nov 26, 2025 · The Nrf2 pathway is a central biological process in health maintenance and the biology of aging, making it a major focus in longevity and disease prevention studies.

Jan 9, 2023 · In this opinion article we describe the rationale for targeting NRF2, summarise the recent advances in drug development of NRF2 modulators, and reflect on the remaining challenges in …

Sep 13, 2025 · Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that acts as a key regulator in cellular defense mechanisms against oxidative stress and xenobiotics.

In this context, accumulating evidence indicates that the transcription factor Nrf2 plays a pivotal role controlling the expression of antioxidant genes that ultimately exert anti-inflammatory functions.

The NRF2 gene is the subject of ongoing research for inflammatory-based diseases because it controls the expression of many critical antioxidant systems. Indeed, numerous associations between …

Canonical Nrf2 activation refers to oxidation or electrophilic modification of the cysteine of KEAP1, resulting in conformational changes in the KEAP1–Nrf2 complex that prevent degradation of Nrf2 …