🧠 Depression doesn’t live only in our thoughts — it lives in the brain. And how we treat the brain matters. 🎥 In this video, Dr. Luehr explains one of the most common questions we hear at Sonder: What’s the difference between treating depression with medication versus TMS? Here’s the simple version: 💊 How antidepressants work Medications primarily work chemically. They increase or balance neurotransmitters like serotonin, dopamine, and norepinephrine by influencing their release or reuptake.

💙 A new chapter in depression treatment. For decades, most antidepressants have worked through similar pathways — targeting serotonin, norepinephrine, and dopamine. But for many people, those options aren’t enough. Spravato® (esketamine) represents a different approach — the first FDA-approved depression treatment in decades that works through the brain’s glutamate system, supporting new neural connections and brain communication in a unique way. This matters for individuals with treatment-resi

Biological basis of depression

Norepinephrine | Definition, Formula & Effects